Sparse Hierarchical Representation Learning on Functional Brain Networks for Prediction of Autism Severity Levels.

Machine learning algorithms have been widely applied in diagnostic tools for autism spectrum disorder (ASD), revealing an altered brain connectivity. However, little is known about whether an magnetic resonance imaging (MRI)-based brain network is related to the severity of ASD symptoms in a large-scale cohort. We propose a graph convolution neural network-based framework that can generate sparse hierarchical graph representations for functional brain connectivity. Instead of assigning initial features for each node, we utilized a feature extractor to derive node features and the extracted representations can be fed to a hierarchical graph self-attention framework to effectively represent the entire graph. By incorporating connectivity embeddings in the feature extractor, we propose adjacency embedding networks to characterize the heterogeneous representations of the brain connectivity. Our proposed model variants outperform the benchmarking model with different configurations of adjacency embedding networks and types of functional connectivity matrices. Using this approach with the best configuration (SHEN atlas for node definition, Tikhonov correlation for connectivity estimation, and identity-adjacency embedding), we were able to predict individual ASD severity levels with a meaningful accuracy: the mean absolute error (MAE) and correlation between predicted and observed ASD severity scores resulted in 0.96, and r = 0.61 (P < 0.0001), respectively. To obtain a better understanding on how to generate better representations, we investigate the relationships between the extracted feature embeddings and the graph theory-based nodal measurements using canonical correlation analysis. Finally, we visualized the model to identify the most contributive functional connections for predicting ASD severity scores.

When does subordinate performance strengthen abusive supervision? A study of a three-way interaction in Korean military.

Drawing on the moral exclusion theory and resource allocation perspective, we examine the association between supervisor perception of subordinate performance and abusive supervision (AS), and the interaction effects of a supervisor's need for achievement and second-level superiors' close monitoring of first-line supervisors, as key boundary conditions for the performance-AS relationship. We conducted a time-lagged survey with 142 matched reports from supervisors and subordinates who had direct reporting relationships with the supervisors in the South Korea military. The results of this study indicate that subordinate performance, as rated by the supervisor, was negatively associated with AS. Furthermore, a supervisor's need for achievement moderated the relationship between subordinate performance and AS, such that the relationship was more negative under a supervisor who had a higher need for achievement. In addition, second-level superiors' close monitoring of first-line supervisors moderated the effect of the interaction of subordinate performance and a supervisor's need for achievement on AS, such that the existing moderation effect of a supervisor's need for achievement is more pronounced when supervisors are under high close monitoring by their superiors. Our investigation of antecedents of supervisor's abusive behavior could help expand our previous knowledge regarding the mechanism of the performance-AS relationship.

Effects of Anger and Moral Identity on the Relationship between Supervisors' Incivility and Deviant Behavior: A Study of Public Service Officers in Republic of Korea.

This study investigated the effects of supervisors' incivility regarding employees' deviant behavior, the mediating effect of anger, and the moderating role of moral identity in the relationship between incivility and deviant behavior. To test our hypotheses, we collected data from supervisor-employee dyads in South Korean military units, applying a time-lagged design, hierarchical regression, and SPSS macro. The results elicited three relevant findings. First, supervisors' incivility was found to positively influence employees' deviant behavior. Second, employees' anger was confirmed to have a mediating effect between supervisors' incivility and employees' deviant behavior. Third, the analysis demonstrated that moral identity moderates the relationship between anger and deviant behavior, and incivility through anger has an indirect effect on deviant behavior. These findings imply that supervisors' incivility, which is readily observed within the organization, is a harmful behavior that increases anger and deviant behavior. These findings suggest that negative leadership should be minimized and employees with high moral identity should be selected to reduce deviant behavior that harms the organization.

Coworker Trust and Knowledge Sharing among Public Sector Employees in Kenya.

This study investigates the association between coworker trust and knowledge sharing among public sector employees with additional consideration of team-member exchange (TMX). It also accounts for the use of supportive technology as a determinant of coworker trust. The study aims to develop a framework to help organizations understand the complex associations among coworker trust, exchange, and knowledge sharing and recognizes the roles of supportive technology and task interdependence in those associations. A cross-sectional survey of 255 employees at three Kenyan public organizations was analyzed. A hierarchical regression analysis tested five hypotheses in eight models to estimate direct, moderating, and mediating relationships. Coworker trust was positively related to knowledge sharing and TMX. Supportive technology significantly moderated the relationships; however, task interdependence was not statistically significant. The results imply that organizations might increase knowledge sharing by focusing on building trustful bonds among workers.

Crab-Shell Biotemplated SnO2 Composite Anodes for Lithium-Ion Batteries.

SnO2 composite materials infiltrated into the hollow carbon channels of a crab-shell biotemplate were hydrothermally synthesized and utilized as anodes for lithium-ion batteries. Varying the reaction temperatures and times of the hydrothermal reaction yielded different SnO2 nanoparticle shapes, characterized by scanning electron microscopy and transmission electron microscopy. The materials prepared at 100 °C (sample S100) were spherical, amorphous in nature, and successfully infiltrated into the hollow carbon channels, while those prepared at 180 °C (sample S180) yielded many rod-like particles on the outer surfaces of the channels. The S100 electrode exhibited better cyclability, corresponding to a capacity of 298 mAh g-1 at 100 cycles, and high rate capability with a capacity retention of 54% at 3 A g-1. The enhanced electrochemical performance of S100 could be attributed to the configuration of the SnO2 particles infiltrating the carbon-coated hollow channels, which accommodated large volume changes during (de)lithiation.

Comparison of the long-term efficacy and safety of generic Tacrobell with original tacrolimus (Prograf) in kidney transplant recipients.

This study aimed to evaluate the long-term efficacy and safety of a generic tacrolimus (Tacrobell [TCB]) compared to the original tacrolimus (Prograf [PGF]) in kidney transplant recipients. In this retrospective observational study, we analyzed the data from 444 patients who took TCB as a first-line immunosuppressive drug and 245 patients who took PGF. The 5-year graft survival rate was 92% for patients in the PGF group and 97% for patients in the TCB group, respectively. Cox proportional hazards for a one-sided, noninferiority model showed noninferiority (upper confidence interval [CI] limit of the hazard ratio [HR]<1.2) for TCB compared to PGF (HR: 0.58; 95% CI: 0-1.14). The 5-year patient survival rate was 96% for patients in the PGF group and 97% for patients in the TCB group. Cox proportional hazards for a one-sided, noninferiority model showed noninferiority (upper confidence interval limit of the HR<2.0) for TCB compared to PGF (HR: 0.83; 95% CI: 0-1.95). The 5-year acute rejection-free graft survival rate was not significantly different between the groups (TCB 67%, PGF 68.8%; P=0.6286). The incidence of adverse events including adverse cardiovascular or cerebrovascular events, malignancies, new-onset diabetes after transplantation, and infection events did not differ significantly between the two groups. We conclude that TCB is a comparable alternative to the original tacrolimus as a first-line immunosuppressive drug. Producers of generics should support further study of their products after approval to assure physicians of their efficacy and safety.

Development of Epidural and Paraspinal Abscesses after Insufficient Evaluation and Treatment of Acute Pyelonephritis Caused by Staphylococcus aureus.

Diagnoses of pyelonephritis caused by Staphylococcus aureus should be accompanied by investigations of concomitant bladder obstruction and metastatic infections, especially to the spine or heart. Complicated pyelonephritis due to S. aureus requires more than 2 weeks of antibiotics, which is the typically recommended treatment duration for pyelonephritis. We describe a patient who was diagnosed with complicated epidural and paraspinal abscesses after insufficient evaluation and treatment of acute pyelonephritis due to S. aureus. A 62-year-old man with type 2 diabetes was admitted with fever, increased urinary frequency, and left flank pain. He was diagnosed with acute pyelonephritis caused by S. aureus. His fever and flank pain subsided after 3 days of intravenous antibiotics. Evaluation of bladder obstruction and metastatic infection were not performed, as he declined further evaluation. The patient was discharged with oral antibiotics and was requested to attend weekly appointments but was lost to follow-up. One month later, the patient presented at the outpatient clinic with similar symptoms. Computed tomography showed recurrent pyelonephritis and a distended bladder. His flank pain persisted despite administration of an opioid agent. Therefore, magnetic resonance imaging was performed, revealing epidural and paraspinal abscesses. Ultrasound-guided aspiration of the paraspinal muscle layer was performed, and blood and percutaneous aspirated fluid cultures revealed S. aureus growth. The pattern of antimicrobial sensitivity was identical to that at his first admission. Following more than 4 weeks of antibiotics, magnetic resonance imaging showed the abscesses had decreased in size. The patient was discharged without neurologic sequelae and was provided with oral antibiotics.